The Department of Surgery of the Maastricht University Hospital, Netherlands, published an article in this month's issue of the World Journal of Surgery.
The aim of this study was to elucidate the causes of hepatocellular injury in patients undergoing liver resection.Markers of hepatocyte injury (AST, GSTa, and L-FABP) and inflammation (IL-6) were measured in plasma of patients undergoing liver resection with and without intermittent inflow occlusion.
The aim of this study was to elucidate the causes of hepatocellular injury in patients undergoing liver resection.Markers of hepatocyte injury (AST, GSTa, and L-FABP) and inflammation (IL-6) were measured in plasma of patients undergoing liver resection with and without intermittent inflow occlusion.
During liver manipulation, liver injury markers increased significantly. Intermittent hepatic
inflow occlusion, anesthesia, and liver transection did not further enhance arterial L-FABP and GSTa levels. Hepatocyte injury was followed by an inflammatory response.
This study shows that liver manipulation is a leading cause of hepatocyte injury during liver surgery. A potential causal relation between liver manipulation and systemic inflammation remains to be established; but since the inflammatory response is apparently initiated early
during major abdominal surgery, interventions aimed at reducing postoperative inflammation and related complications should be started early during surgery or beforehand.
World J Surg (2007) 31:2033–2038
* If you want to read this article, you can download it for free from the "BOX" widget, in the left column.
inflow occlusion, anesthesia, and liver transection did not further enhance arterial L-FABP and GSTa levels. Hepatocyte injury was followed by an inflammatory response.
This study shows that liver manipulation is a leading cause of hepatocyte injury during liver surgery. A potential causal relation between liver manipulation and systemic inflammation remains to be established; but since the inflammatory response is apparently initiated early
during major abdominal surgery, interventions aimed at reducing postoperative inflammation and related complications should be started early during surgery or beforehand.
World J Surg (2007) 31:2033–2038
* If you want to read this article, you can download it for free from the "BOX" widget, in the left column.
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